vicissitude

English Thesaurus

1. mutability in life or nature (especially successive alternation from one condition to another) (noun.attribute)

hypernym	:	mutability, mutableness,
definition	:	the quality of being capable of mutation (noun.attribute)

2. a variation in circumstances or fortune at different times in your life or in the development of something (noun.event)

hypernym	:	fluctuation, variation,
definition	:	an instance of change; the rate or magnitude of change (noun.event)