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thalassaemia major

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1. a fatal form of homozygous thalassemia (inherited from both parents) in which there is no hemoglobin; skeletal deformations; heart and spleen and liver enlarged (noun.state)
:mediterranean anaemia, mediterranean anemia, thalassaemia, thalassemia,
definition:an inherited form of anemia caused by faulty synthesis of hemoglobin (noun.state)

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